Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress.
RatEndotoxin/LPSSprague-Dawleymalen = 75 neonatal rats in total, 15 per group across five groupsintraperitoneal in the LPS plus narciclasine group; subcutaneous injection into the neck is described for the narciclasine-only group0.7 mg/kg in 200 microlitres12 h prior to LPS exposure
Model: Lipopolysaccharide-induced neonatal acute lung injury (LPS 2 mg/kg intraperitoneally)
Narciclasine reduced histological lung injury and pulmonary oedema, lowered serum cytokines and lung adhesion molecules, decreased ROS, LDH and MPO while increasing SOD, reduced apoptosis, and suppressed TLR4/NF-kappaB/Cox2 pathway activation.
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