THERAPY DOSSIER · th-f56b2cd0771c

Electroacupuncture

Procedure · Physical procedure: low-frequency pulsed electrical current delivered through inserted acupuncture needles. Proposed mechanisms include segmental and supraspinal modulation of nociceptive transmission, endogenous opioid and adenosine release, and cholinergic anti-inflammatory (vagal) signalling. No ChEMBL entity is possible for a procedure.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Physical procedure: low-frequency pulsed electrical current delivered through inserted acupuncture needles. Proposed mechanisms include segmental and supraspinal modulation of nociceptive transmission, endogenous opioid and adenosine release, and cholinergic anti-inflammatory (vagal) signalling. No ChEMBL entity is possible for a procedure.
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01020266 ↗Injury indicationNAcompleted

Cerebral protective effects of repeated electroacupuncture pretreatment in heart valve replacement surgery

Stroke · Brain Injuries

Enrolment: 300 · Results not recorded

NCT05262816 ↗NAunknown

Urodynamic analysis of the effect of electroacupuncture at different acupoints on bladder function after spinal cord injury

Neurogenic Bladder

Enrolment: 34 · Results not recorded

NCT04189237 ↗NAunknown

Electroacupuncture improves pain and wrist functionality in patients undergoing rehabilitation therapy after distal radius fracture

Electroacupuncture

Enrolment: 30 · Results not recorded

NCT07545785 ↗NArecruiting

Effectiveness of electroacupuncture combined with cupping therapy in patients with shoulder tendinitis

Shoulder Tendinopathy · Shoulder Tendinitis

Enrolment: 54 · Results not recorded

NCT07292506 ↗NAactive not recruiting

Impact of acupuncture (including electroacupuncture) on biomarkers of brain injury and inflammatory response in migraine

Migraine

Enrolment: 75 · Results not recorded

NCT00523016 ↗NAcompleted

Pilot study of acupuncture treatment to reduce below-level neuropathic pain in spinal cord injury

Neuropathic Pain

Enrolment: 33 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32301816 ↗2020Reported benefit

The poly-ADP ribose polymerase-1/apoptosis-inducing factor pathway may help mediate the protective effect of electroacupuncture on early brain injury after subarachnoid hemorrhage.

RatHaemorrhage/shockUnspecifiedSprague-Dawley

Model: Subarachnoid haemorrhage model in rats, assessing early brain injury

Electroacupuncture reduced apoptosis, PARP-1/AIF pathway protein expression, blood-brain barrier permeability, cerebral oedema and microglial activation after subarachnoid haemorrhage. Neurological function improved significantly.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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Electroacupuncture