THERAPY DOSSIER · th-f4476d47e0a0

Nasal olfactory ecto-mesenchymal stem cells (syngeneic graft)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29357739 ↗2018Reported benefit

Grafts of Olfactory Stem Cells Restore Breathing and Motor Functions after Rat Spinal Cord Injury.

RatSpinal cord injuryContusionInbred F344Intraspinal transplantation into the injured spinal cordDelayed transplantation two days after contusion

Model: Acute high cervical contusion spinal cord injury causing persistent hemidiaphragmatic and foreleg paralysis

Grafting improved breathing movements, ipsilateral phrenic nerve and diaphragm activity and locomotor ability at four months, with reduced axonal disorganisation and inflammation and some grafted cells adopting a neuronal phenotype.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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