THERAPY DOSSIER · th-f3f77925582c

Stem cells from human exfoliated deciduous teeth (SHED), undifferentiated and neurally induced (iSHED)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01814436 ↗Injury indicationNAunknown

Revitalization of Young Immature Permanent Teeth With Necrotic Pulps Using Autologous Stem Cells From Human Exfoliated Deciduous Teeth

Dental Pulp Necrosis · Permanent Incisor Avulsed by Trauma

Enrolment: 80 · Results not recorded

NCT07734974 ↗PHASE1/PHASE2completed

Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone

Clift Lip · Cleft Palate · Alveolar Bone Loss · Postoperative Pain

Enrolment: 20 · Results not recorded

NCT03957655 ↗EARLY_PHASE1unknown

Safety and Efficacy of Stem Cells From Human Exfoliated Deciduous Teeth for Treatment of Decompensated Liver Cirrhosis

Liver Cirrhosis

Enrolment: 40 · Results not recorded

NCT05728346 ↗NAnot yet recruiting

A Single-arm Clinical Trial Evaluating the Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization in Patients With Pulp Necrosis of Permanent Teeth

Pulp Necroses

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21970342 ↗2011Reported benefit

Transplantation of undifferentiated and induced human exfoliated deciduous teeth-derived stem cells promote functional recovery of rat spinal cord contusion injury model.

RatSpinal cord injuryContusionWistarMaleTransplanted in the acute phase after contusion injury, with assessment up to 5…

Model: Acute contusive spinal cord injury in rats at the thoracic level

Both SHED and induced SHED groups showed significant locomotor functional recovery relative to vehicle and control groups, with the induced SHED group in a better state than the undifferentiated SHED group. Grafted cells showed neuronal and glial differentiation, and the induced SHED group had incr…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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