Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis.
MixedChemical/toxinWistar rats used for the dermal irritation and corrosion test; mouse strain not statedMaleTopical
Model: Acute and chronic ear dermatitis in mice, with oedema induced by topical croton oil, arachidonic acid, capsaicin, ethyl phenylpropiolate and phenol, and by subcutaneous histamine injection; chronic model used multiple croton oil applications
The hexane fraction markedly reduced the inflammatory response to all irritants tested except arachidonic acid, an effect linked at least in part to reduced IL-6 and TNF-alpha levels. Activity against croton oil was abolished by mifepristone, suggesting a glucocorticoid-like mechanism, and the acut…
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