THERAPY DOSSIER · th-f24588f9924d

Aloe vera

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02819817 ↗Injury indicationPHASE1/PHASE2withdrawn

A Randomised Controlled Trial of Topical Aloe Vera Gel in Emergency Department Patients Presenting With Simple Traumatic Wounds

Injuries and Wounds

Enrolment: 0 · Results not recorded

NCT04325490 ↗PHASE4completed

Liquid Powder Containing Tapioca Starch, Aloe Barbadensis, Rose Hip Oil and Allantoin vs Topical 1% Hydrocortisone Cream for Intertrigo

Intertrigo

Enrolment: 40 · Results not recorded

NCT04964167 ↗PHASE4completed

Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Chronic Periodontitis

Periodontitis · Periodontal Inflammation

Enrolment: 150 · Results not recorded

NCT02437747 ↗PHASE4completed

Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis Patients With Controlled Diabetes Mellitus

Diabetes Mellitus · Chronic Periodontitis

Enrolment: 15 · Results not recorded

NCT00156806 ↗PHASE3completed

Investigating the Therapeutic Effectiveness of Aloe Barbadensis in Reducing Cutaneous Side-Effects of Radiation Treatment for Breast Cancer

Breast Cancer

Enrolment: 231 · Results not recorded

NCT02735200 ↗PHASE2completed

Topical Delivery of Vitamin D3: A Randomized Controlled Trial (Aloe Vera Gel Comparator)

Vitamin D Deficiency

Enrolment: 550 · Results not recorded

NCT04833998 ↗PHASE2unknown

Hydration Based on Thioctaine, Aloe Vera and Calendula in the Prevention of Hand-Foot Syndrome in Patients Using Capecitabine: TACX Care Trial

Hand-foot Syndrome

Enrolment: 54 · Results not recorded

NCT04753775 ↗NAcompleted

Randomized, Double-Blind, Placebo-Controlled Trial of Enema Aloe Vera Gel for Achieving Remission in Active Ulcerative Proctosigmoiditis

Ulcerative Colitis · Proctosigmoiditis

Enrolment: 44 · Results not recorded

NCT06190028 ↗NAterminated

Performance and Safety of IRIDIUM A Gel Preservative-free Ophthalmic Solution in Glaucoma or Ocular Hypertension With Concomitant Dry Eye Syndrome

Dry Eye Syndrome · Glaucoma · Ocular Hypertension

Enrolment: 65 · Results not recorded

NCT06243601 ↗NAcompleted

Effect of Aloe Vera Gel as an Intra Canal Medicament in Patients With Asymptomatic Periapical Lesions

Periapical Diseases

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21396624 ↗2011Reported benefit

Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-beta and fibroblast growth factor production.

RatRadiationoralafter 3 days of local radiation, from wounding

Model: skin excision wound after localised radiation (radiation-delayed wound)

Oral Aloe vera accelerated radiation-delayed wound healing with increased TGF-beta1 and bFGF and enhanced angiogenesis.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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