Adiponectin protects against lung ischemia-reperfusion injury in rats with type 2 diabetes mellitus.
RatIschaemia-reperfusionOther / unspecifiedWistarMalen = 36 male Wistar rats allocated to 6 groups; statistical comp…Injection via an indwelling right femoral vein catheter used for drug and fluid administration10 micrograms per rat10 minutes prior to reperfusion, that is during the 90-minute ischaemic period
Model: Left lung hilum clamped for 90 minutes of ischaemia followed by 4 hours of reperfusion, in normal rats and in rats with type 2 diabetes induced by 4 weeks of high fat diet plus streptozotocin 35 mg/kg intraperitoneally (fasting plasma glucose at least 11.1 mmol/l)
Type 2 diabetes exacerbated lung ischaemia-reperfusion injury, with higher IL-6, TNF-alpha, wet to dry ratio, lung injury score, oxidative stress and apoptosis and lower oxygenation than normal rats. Globular adiponectin given 10 minutes before reperfusion improved oxygenation and reduced oedema, l…
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