THERAPY DOSSIER · th-efe23c7e60c3

Polypropylene mesh, and polypropylene combined with poliglecaprone mesh

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06258317 ↗NAnot yet recruiting

Mesh Fixation Versus Non Fixation in Laparoscopic Inguinal Hernioplasty

Laparoscopic · Inguinal Hernia · Hernioplasty

Enrolment: 30 · Results not recorded

NCT07210424 ↗Phase not recordednot yet recruiting

Comparative Study on the Post-operative Pain and Other Outcomes of Mesh Fixation With Prolene vs Vicryl vs Skin Staples in Lichtenstein Inguinal Hernia Repair

Inguinal Hernia

Enrolment: 132 · Results not recorded

NCT01592942 ↗NAunknown

A Randomized Multi-centre Study of Tissue Glue Fixation of Optilene Mesh With Histoacryl or Self-gripping Parietex ProGrip Compared to Conventional Non-absorbable Suture Fixation of Ultrapro Mesh

Inguinal Hernia

Enrolment: 650 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25185056 ↗2014Mixed findings

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats.

RatWoundWistarMalen = 77 rats across three groupsSurgical implantation at the abdominal wall defectAt the time of defect creation

Model: Surgically created muscular and aponeurotic abdominal wall defect

Polypropylene mesh gave a regular and ascending gain in tensile strength that stabilised by day 28, while the polypropylene with poliglecaprone mesh gave uneven gains and was weaker at day 14. Final strengths were similar. Inflammation was more intense with the combined mesh at day 4 and similar th…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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