THERAPY DOSSIER · th-ef777a2c62be

Olfactory lamina propria graft containing olfactory ensheathing cells, compared with respiratory lamina propria graft without olfactory ensheathing cells

Biologic · Cell therapy (olfactory ensheathing cell graft); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (olfactory ensheathing cell graft); not a ChEMBL entity
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07596563 ↗Injury indicationPHASE1not yet recruiting

Olfactory Cell Transplantation With Intensive Rehabilitation for Chronic Traumatic Spinal Cord Injury

Spinal Cord Injury

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23179588 ↗2012No effect reported

Implications of olfactory lamina propria transplantation on hyperreflexia and myelinated fiber regeneration in rats with complete spinal cord transection.

RatSpinal cord injuryComplete transectionSprague-DawleyMaleTransplantation into the spinal cord lesion siteAcute, 2 week delayed and 4 week delayed transplantation

Model: Complete spinal cord transection in adult rats

Neither olfactory nor respiratory lamina propria grafts produced considerable improvement in withdrawal reflex responses or in low-frequency dependent depression of the H-reflex, and the two graft types gave comparable myelinated fibre density and estimated total fibre number at the lesion site. An…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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