Development of microRNA-21 mimic nanocarriers for the treatment of cutaneous wounds.
MouseWoundBALB/cMaleIntradermal injection of about 60 microL into the dermis at four sites around the wound plus topical application of a further 20 microL onto the wound bed2.5 microM miR21 per treatment in the main experiment, give…Day 0 (day of wounding) and day 4 post-injury; dose-response and nepidermin com…
Model: Excisional wound splinting model. Two full-thickness excisional wounds created on the dorsal surface with 6 and 8 mm disposable biopsy punches, a 0.5 mm thick donut-shaped silicone splinting ring secured around the wound, dressed with Tegaderm and Coban
miR21/DA3 accelerated wound closure in a dose-dependent manner, with 100 per cent of the wound still open for saline versus 57 per cent for 5 microM miR21/DA3 at day 8 and complete closure by day 16 in the 5 microM group, while inhibitor-miR21/DA3 significantly delayed healing. Histology showed red…
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