THERAPY DOSSIER · th-ebedc1b1c141

Sipunculus nudus L. polysaccharide (SNP) combined with WR-2721 (amifostine), rhIL-11 and rhG-CSF

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25852150 ↗2015Reported benefit

Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice.

MouseRadiationICR (Imprinting Control Region)malen = 70 mice divided into seven groups

Model: Acute radiation injury from whole-body exposure to a 5 Gy cobalt-60 gamma-ray beam

Combined administration of SNP with WR-2721, rhIL-11 and rhG-CSF produced synergistic recovery of peripheral WBC, RBC and platelet counts and haemoglobin, and synergistic promotion of spleen, thymus, testicle, bone marrow nucleated cell and sperm counts. Serum SOD activity and testosterone increase…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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