THERAPY DOSSIER · th-ebae59373425

Acute intermittent hypoxia combined with task-specific motor training

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

5 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05341466 ↗Injury indicationNAcompleted

Changes in Corticospinal Excitability and Motor Learning After Acute Intermittent Hypoxia

Incomplete Spinal Cord Injury

Enrolment: 56 · Results not recorded

NCT06520358 ↗Injury indicationNAcompleted

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Traumatic Brain Injury

Enrolment: 5 · Results not recorded

NCT03262766 ↗Injury indicationNAunknown

Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI

Spinal Cord Injuries

Enrolment: 80 · Results not recorded

NCT03922802 ↗Injury indicationNAcompleted

Locomotor Function Following AIH and Transcutaneous Electrical Spinal Cord Stimulation With Gait Therapy

Spinal Cord Injuries · Spinal Cord Diseases

Enrolment: 14 · Results not recorded

NCT02274116 ↗Injury indicationNAactive not recruiting

Repetitive Exposure of Intermittent Hypoxia to Enhance Walking Recovery in Chronic Spinal Cord Injury

Spinal Cord Injuries

Enrolment: 30 · Results not recorded

NCT03453697 ↗NAunknown

Effects of Acute Intermittent Hypoxia on Brain Function Imaging and Systemic Inflammation

Hypoxemia

Enrolment: 15 · Results not recorded

NCT05164705 ↗NAcompleted

Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia

Healthy Brain Perfusion

Enrolment: 33 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25664481 ↗2015Mixed findings

Delayed Intervention with Intermittent Hypoxia and Task Training Improves Forelimb Function in a Rat Model of Cervical Spinal Injury.

RatSpinal cord injuryUnspecifiedLewisMaleInhaled intermittent hypoxiaBeginning 4 weeks after injury (delayed intervention)

Model: Incomplete cervical spinal cord injury

Acute intermittent hypoxia with concurrent ladder-specific training reduced footslips on the ladder task for up to 2 months compared with sham treatment, but produced no benefit without task-specific training and no improvement on reach-to-grasp or unskilled forepaw tasks.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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