THERAPY DOSSIER · th-ead38528f8b0

Buddleja cordata methanolic extract (BCME)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25086781 ↗2014Reported benefit

Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice.

MouseRadiationSKH-1 hairlessFemalen = 25 mice, five groups of five mice each; a further n = 5 for…Topical application to dorsal skin200 µL of a 2 mg/mL ethanolic solution applied to a 6 cm2 d…15 minutes before UVB irradiation

Model: Acute UVB-induced skin damage: dorsal skin irradiated with UVB lamps (302 nm, 6 W) positioned 15 cm above the back, delivering 6 mJ/cm2 over a 10-minute exposure

Topical BCME protected against acute UVB-induced skin damage. Irradiated BCME-treated mice showed less redness than irradiated vehicle controls, and skin from the BCME plus UVB group showed only slight epidermal thickening with no vessel congestion or epidermal and dermal oedema, and fewer sunburn…

Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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