Antifibrosis oligodeoxynucleotide 4 (AFODN4), a dual-functional AP-1 and SMAD decoy oligodeoxynucleotide

A dual AP-1 and SMAD decoy ODN suppresses tissue fibrosis and scarring in mice.

Model: Acute dermal wounds in mice, with in vitro studies in L929 murine fibroblasts and NIH 3T3 cells

Local administration of AFODN4 significantly inhibited fibrosis associated with acute dermal wounds in mice and inhibited AP-1 mediated proinflammatory mediator production that otherwise follows SMAD blockade alone. Dual inhibition of SMAD and AP-1 is proposed as an antifibrotic strategy.

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