THERAPY DOSSIER · th-e7ed52875303

Epidural spinal cord stimulation delivered through a miniature electrode

Device · Implanted neuromodulation device; no chemical entity, ChEMBL not applicable.

Evidence & regulatory context

Mechanism: Implanted neuromodulation device; no chemical entity, ChEMBL not applicable.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04241250 ↗Injury indicationPHASE2completed

Transspinal versus epidural stimulation for exoskeletal assisted walking after spinal cord injury

Spinal Cord Injury

Enrolment: 4 · Results not recorded

NCT06533969 ↗Injury indicationNArecruiting

Assessment of neural signals for the control of assistive devices (epidural spinal cord stimulation)

Spinal Cord Injury

Enrolment: 3 · Results not recorded

NCT06515223 ↗Injury indicationNArecruiting

Improving pelvic rehabilitation using epidural stimulation after spinal cord injury

Spinal Cord Injuries · Neurogenic Bladder · Neurogenic Bowel

Enrolment: 20 · Results not recorded

NCT07207798 ↗Injury indicationNArecruiting

Epidural electrical stimulation for motor and sensory function reconstruction in spinal cord injury (T11-L3)

Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT06650202 ↗Injury indicationNArecruiting

Improving balance after spinal cord injury using a robotic upright stand trainer and spinal cord epidural stimulation

Spinal Cord Injury

Enrolment: 20 · Results not recorded

NCT07412808 ↗Injury indicationNAnot yet recruiting

Spinal cord stimulation assisted by motor rehabilitation training for restoring motor function in non-traumatic spinal cord injury

Spinal Cord Disease · Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT01990287 ↗NAterminated

SENSE: subcutaneous and epidural neuromodulation system evaluation for chronic low back and leg pain

Failed Back Surgery Syndrome · Low Back Pain

Enrolment: 38 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31162783 ↗2019Mixed findings

Modulation of Spinal Nociceptive Transmission by Sub-Sensory Threshold Spinal Cord Stimulation in Rats After Nerve Injury

RatOtherSprague-Dawley (from PubMed MeSH indexing; not stated in the abstract)Male (from PubMed MeSH indexing; not stated in the abstract)n = n = 7-10 per group for stimulation at T13-L1; n = 8-10 per…Epidural, with the electrode placed at the T13-L1 or L2-L3 spinal levels; bipolar configurationSub-sensory threshold stimulation at 90% of A-beta threshol…After spinal nerve ligation; the interval between ligation and stimulation is n…

Model: L5 spinal nerve ligation producing peripheral neuropathic nerve injury

Traditional suprathreshold spinal cord stimulation at T13-L1 significantly reduced C-fibre evoked local field potentials. Sub-sensory threshold stimulation at 200 Hz and 500 Hz also reduced C-LFP, but to a lesser extent than traditional stimulation, whereas 1200 Hz and 10 000 Hz sub-threshold stimu…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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