Radioprotective Activity of the Nitric Oxide Synthase Inhibitor T1023. Toxicological and Biochemical Properties, Cardiovascular and Radioprotective Effects.
MixedRadiationWistar rats (mouse strain not stated)MaleIntraperitonealLD10 317 mg/kg and LD50 410 mg/kg in mice; radioprotective…Prophylactic, 5 to 120 minutes before total-body irradiation
Model: Total-body irradiation causing haematopoietic and gastrointestinal acute radiation syndrome
T1023 acted as a hypoxic radioprotector with a dose modifying factor of 1.6 to 1.9, reducing early bone marrow devastation by about 40%, lessening maximal neutropenia and thrombocytopenia 2 to 2.5 fold and shortening recovery time by 30 to 40%, but only when given before irradiation.
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