THERAPY DOSSIER · th-e763ff2ca860

Iron supplementation as ferric chloride (FeCl3)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06049693 ↗PHASE4completed

Iron Prehabilitation and Perioperative Infectious Diseases of Endometrial Cancer Patients (ferrous gluconate 300 mg)

Endometrial Cancer · Perioperative Complication · Prehabilitation

Enrolment: 156 · Results not recorded

NCT04083755 ↗PHASE4unknown

Impact of Intravenous Iron Treatment of Preoperative Anaemia in Patients With Lower Extremity Peripheral Artery Disease (ferric carboxymaltose)

Anemia · Peripheral Arterial Occlusive Disease

Enrolment: 240 · Results not recorded

NCT03010579 ↗PHASE4unknown

Efficacy and Safety of Erythropoietin in the Treatment of Anaemia in Patients With Lymphoma After Autologous Haematopoietic Stem Cell Transplantation (with iron supplementation)

Anemia · Lymphoma

Enrolment: 70 · Results not recorded

NCT01198574 ↗PHASE3completed

The Role of Sub-clinical Inflammation on the Iron Status of Myanmar Anaemic Adolescent Schoolgirls During Iron and Vitamin A Supplementation

Anemia

Enrolment: 402 · Results not recorded

NCT05185024 ↗NAcompleted

A Study of Efficacy and Safety of Three Different Oral Iron-Containing Dietary Supplements in Correction of Haematological Indices and Replenishment of Depleted Iron Stores in Iron Deficient Adults

Iron-deficiency · Iron Deficiency Anemia

Enrolment: 152 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28030490 ↗2017Reported benefit

Modeling Acinetobacter baumannii wound infections: The critical role of iron.

MouseCrushLimb / muscle crushC57BL/6Malen = 15 per group in the injury model experiments; 30 per group…Topical wound washout200 microlitres of 100 mM FeCl3 in 0.9% normal salineImmediately after bacterial inoculation, as the washout solution before skin cl…

Model: Rectus abdominis muscle crush injury with forceps combined with ischaemia produced by double suture ligation of the muscle including the epigastric vascular bundle, followed by inoculation of the wound with 100 microlitres of Acinetobacter baumannii ATCC 19606 suspension for 2 minutes

Combined crush injury, ischaemia and inoculation produced clinical wound infection in 100% of mice, with the highest bacterial burden (about 10^5 CFU/mg) and an approximately threefold increase in HIF1-alpha. Iron washout of the wound prevented wound infection entirely (n = 30 per group, p < 0.0001…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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