Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 2
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
A Phase 1/2a Dose Escalation Study of AST-OPC1 in Subjects With Subacute Cervical Spinal Cord Injury (modality-level oligodendrocyte progenitor surrogate)
Cervical Spinal Cord Injury · Spine Injury · Spinal Cord Trauma
Enrolment: 25 · Results not recorded
Delivery of Oligodendrocyte Progenitor Cells for Spinal Cord Injury: Evaluation of a Novel Device (DOSED), OPC1 (modality-level surrogate)
Spinal Cord Injury, Acute · Spinal Cord Injury Cervical · Spinal Cord Injury Thoracic
Enrolment: 10 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatSpinal cord injuryContusionWistarMaleIntrathecal delivery via lumbar punctureAfter T10 contusive spinal cord injury; exact interval not stated in the abstra…
Model: T10 thoracic contusive spinal cord injury
Transplantation of preconditioned pro-oligodendroblasts improved locomotor recovery and increased intralesional axon numbers and myelination, with less macrophage accumulation, compared with vehicle control or oligodendrocyte progenitor cell transplantation.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.