Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.
RatCrushPeripheral-nerve crushWistarMalen = 48 rats, eight groups of n=6Oral gavage (5 mL/kg)200 mg/kg and 400 mg/kg for each extract; pregabalin 30 mg/…From the first day after injury
Model: Chronic constriction injury of the right sciatic nerve, four loose 4/0 silk ligatures placed 1 mm apart, maintained 14 days
Both extracts dose-dependently reversed thermal and mechanical hyperalgesia and cold and dynamic allodynia by day 14, restored sciatic nerve and brainstem structure and myelin ratio, and normalised oxidative, nitrosative and inflammatory markers, with the high dose exceeding pregabalin on several m…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.