Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha.
RatSpinal cord injuryContusionSprague-DawleyFemale (ovariectomised)n = At least five treatment groups; n=10 per group for estradio…Subcutaneous implant or pellet placed in the midscapular region3 mg estradiol benzoate in a 5 mm silastic implant; 15 mg t…Implanted immediately after ovariectomy, 7 days before spinal cord injury
Model: Moderate T9-T10 contusion spinal cord injury using the NYU impactor, 10 g rod 2.5 mm diameter dropped from 12.5 mm
Estradiol raised mean plasma levels to about 154 pg/mL at injury and improved BBB scores at 7, 14, 21 and 28 days post-injury (for example 14.6 versus 11.8 at 28 days), reduced lesion area and increased spared tissue, effects blocked by the estrogen receptor alpha antagonist MPP. Estradiol reduced…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.