THERAPY DOSSIER · th-e0b429ab617c

Acute ventral root reimplantation (replantation) into the spinal cord

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22696606 ↗2012Reported benefit

Modulation of the visceromotor reflex by a lumbosacral ventral root avulsion injury and repair in rats.

RatOtherSprague-DawleyFemaleSurgicalAcute, at the time of avulsion injury

Model: Unilateral L6-S1 ventral root avulsion (cauda equina injury)

Avulsion prolonged the visceromotor reflex to bladder filling. Acute reimplantation normalised external oblique EMG duration by 3 weeks (versus persistent prolongation after avulsion alone) and limited increased bladder contraction duration to week 1 only, indicating earlier sensory recovery.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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