THERAPY DOSSIER · th-e04a0d86b9ea

RRx-001

Drug · Nibrozetone (RRx-001); minimally-metabolized dinitroazetidine radiosensitizer / NLRP3 inhibitor (no ChEMBL mechanism record).

Not approved Suggest a correction

Evidence & regulatory context

Mechanism: Nibrozetone (RRx-001); minimally-metabolized dinitroazetidine radiosensitizer / NLRP3 inhibitor (no ChEMBL mechanism record).
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL3526802 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: RRx-001; ABDNAZ; Radiosensitizer RRx-001
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05966194 ↗PHASE2active not recruiting

RRx-001 for Attenuation of Severe Oral Mucositis in Chemoradiation

Oral Mucositis

Enrolment: 216 · Results not recorded

NCT02096341 ↗PHASE1terminated

Subcutaneous Route to Facilitate RRx-001 Administration

Malignant Solid Tumor

Enrolment: 2 · Results not recorded

NCT04525014 ↗PHASE1terminated

RRx-001 + Irinotecan/Temozolomide in Pediatric Recurrent Solid/CNS Tumors

CNS Neoplasms

Enrolment: 2 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31038318 ↗2019Reported benefit

Cardioprotective Effect of Phase 3 Clinical Anticancer Agent, RRx-001, in Doxorubicin-Induced Acute Cardiotoxicity in Mice.

MouseChemical/toxinBALB/cMalen = 24 BALB/c mice randomised across four armsProphylactic pretreatment before doxorubicin administration

Model: Doxorubicin-induced acute cardiotoxicity, assessed five days after doxorubicin injection

Relative to doxorubicin-treated mice without RRx-001, RRx-001 pretreatment improved left ventricular systolic pressure by 27%, dP/dt by 25%, stroke volume by 52%, ejection fraction by 20%, stroke work by 62.5%, heart rate by 18%, cardiac output by 57% and mean arterial pressure by 30%, and reduced…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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