Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation.
MouseChemical/toxinC57BL/6Jn = 18 mice total, n=6 per group across 3 groupsOral gavage100 mg extract per kg bodyweight; alcohol 1 g/kg bodyweightAdministered 30 min before each alcohol dose
Model: Acute alcohol-induced hepatic steatosis: ethanol 1 g/kg bodyweight by oral gavage once daily for 5 days
The root bark extract reduced alcohol-elevated transaminases, hepatic and serum triglyceride and lipid droplets, lowered lipogenic and inflammatory proteins, raised SIRT1, AMPK-alpha and PGC1-alpha and reduced oxidative stress markers, although TUNEL apoptosis and CPT1 were unchanged
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.