THERAPY DOSSIER · th-dd9fde6dcad7

polaprezinc (zinc-carnosine)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation · Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL3184454 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: Polaprezinc; Zinc L-carnosine; Zinc carnosine; Promac; Z-103; beta-alanyl-L-histidinato zinc
Note: Not recorded

Clinical trials 8

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07379645 ↗Injury indicationPhase not recordedcompleted

PepZinGI (zinc carnosine) crossover heartburn clinical study

Heartburn

Enrolment: 50 · Results not recorded

NCT03467438 ↗PHASE4unknown

Zinc L-carnosine (Hepilor) in maintaining remission of gastro-oesophageal reflux disease

Gastroesophageal Reflux Disease

Enrolment: 80 · Results not recorded

NCT03997188 ↗PHASE3completed

Hepilor and delay in development of dysphagia in breast cancer patients receiving adjuvant radiotherapy

Breast Cancer Female · Dysphagia

Enrolment: 40 · Results not recorded

NCT04430998 ↗PHASE3unknown

Zinc-L-carnosine-based mouth rinse on periodontal tissues and pain after scaling and root planing

Periodontal Index · Pain

Enrolment: 75 · Results not recorded

NCT05549778 ↗PHASE2completed

Polaprezinc in enzalutamide- or abiraterone-resistant castration-resistant prostate cancer

Castration-resistant Prostate Cancer

Enrolment: 12 · Results not recorded

NCT00149149 ↗PHASE1completed

Zinc carnosine and intestinal permeability in healthy volunteers taking NSAIDs

Healthy

Enrolment: 10 · Results not recorded

NCT02243618 ↗Phase not recordedcompleted

Proton pump inhibitor and polaprezinc combination therapy for healing of ESD-induced ulcer

Gastric Adenoma · Early Gastric Cancer

Enrolment: 153 · Results not recorded

NCT06678997 ↗Phase not recordedcompleted

Polaprezinc/zinc L-carnosine (Hepilor) in infants with gastro-oesophageal reflux

Gastroesophageal Reflux · Infants

Enrolment: 60 · Results not recorded

Preclinical evidence 2

1 studies reported at therapy level; 2 evidence entries itemised.

PMID 21377290 ↗2011Reported benefit

Efficacy of polaprezinc for acute radiation proctitis in a rat model.

RatRadiationWistarFemalen = 54 rats (3 groups)rectal ointment (topical)each day after irradiation

Model: rectal irradiation (radiation proctitis)

Polaprezinc reduced mucosal damage and inflammation compared with controls in acute radiation proctitis.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

PMID 10877238 ↗2000

Polaprezinc exerts a salutary effect on impaired healing of acute gastric lesions in diabetic rats

RatWound

Extraction: mesh. Machine-extracted fields require source verification.

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