An evaluation of the ability of the peripheral vasodilator buflomedil to improve vascular patency after acute frostbite.
RatOtherMalen = Seven groups of rats, group sizes not statedIntravenous (tail vein) or topical in the rewarming bath10 mg/kg by tail vein injection, or 24 mg buflomedil in the…Before cooling, immediately after cooling, or during rewarming
Model: Acute experimental freeze injury of the left hindpaw cooled to footpad temperature of -15 degrees C followed by rapid rewarming at 40 degrees C
There was no significant difference in mean cast weights between frozen hindpaws across the seven groups, although buflomedil increased mean cast weight of control hindpaws in two groups. Buflomedil did not improve vascular patency in this acute frostbite model.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.