The accumulation of T cells within acellular nerve allografts is length-dependent and critical for nerve regeneration.
RatOtherLewis recipients, Sprague-Dawley graft donors, and athymic rnu/rnu and rnu/+ ratsMale, with a comparison set of female rats receiving 2 cm allograftsn = n=6 to 8 per group for 8 week regeneration endpoints; n=4 p…Surgical implantation into the nerve gap with 9-0 nylon microsutureGraft lengths of 2 cm or 4 cm; re-grafting experiments used…Immediately at the time of nerve transection
Model: Sciatic nerve transection 5 mm proximal to the distal trifurcation with a nerve gap repaired by a graft
Short 2 cm allografts supported nearly 10,000 myelinated axons at mid-graft and distally, whereas 4 cm allografts supported fewer than 1,000 and almost none distally. Long allografts showed reduced angiogenesis, fewer Schwann cells with an altered phenotype, fewer CD3 positive T cells and lower IFN…
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