Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1 Cell Depletion and Blockage of CD47/CD172a Signaling.
MouseBurnScaldCD1 outbredMalen = n = 8 controls and n = 12 scald for cytokine time course; f…Intraperitoneal injection100 micrograms anti-Gr1 in 100 microlitres sterile PBSDay 6 after scald injury, with spleens harvested on day 7
Model: Scald burn injury, 28% total body surface area, full thickness, with intraperitoneal resuscitation using 1.5 mL sterile normal saline
Scald injury suppressed CD4 and CD8 T cell activation and cytokine production acutely and persistently for at least 11 days, through an extrinsic, contact-dependent mechanism. Depletion of Gr1 positive myeloid-derived suppressor cells and blockade of the CD172a ligand CD47 each mitigated the T cell…
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