THERAPY DOSSIER · th-da66b9919ec3

Perfluorochemical emulsion (Fluosol-43, oxypherol) with 100 per cent oxygen breathing

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL1371129 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: Perfluorodecalin; Fluosol da perfluorodecalin; Acri-deca; NSC-97066; Perflunafeno
Note: Not recorded

Clinical trials 3

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03668665 ↗Injury indicationPHASE3withdrawn

Hyaluronic Acid With Perfluorodecalin and Physalis Angulata Extract After Split Skin Removal

Wound Healing

Enrolment: 0 · Results not recorded

NCT00592280 ↗EARLY_PHASE1terminated

Two-Layer Method (perfluorocarbon) Preservation and Resuscitation of the Cadaveric Pancreas Before Transplantation

Graft Pancreatitis

Enrolment: 7 · Results not recorded

NCT01959568 ↗NAunknown

Double Endotamponade With Perfluorodecalin and Silicone Oil in Retinal Detachment Surgery

Retinal Detachment

Enrolment: 290 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2773159 ↗1989Reported benefit

Effects of intravenous perfluorocarbon and oxygen breathing on acute decompression sickness in the hamster.

HamsterOtherFemalen = 48 hamsters, three groups of 16Intravenous, with inhaled 100 per cent oxygenImmediately after removal from the hyperbaric chamber

Model: Acute decompression sickness after 30 min at 7 ATA followed by direct decompression to surface at 60 fsw/min

Survival was 6 per cent untreated, 62 per cent with saline plus oxygen and 94 per cent with perfluorochemical plus oxygen. Perfluorochemicals reduced bubble numbers, enhanced bubble disappearance and reduced dysrhythmias.

Extraction: extract · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.

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