THERAPY DOSSIER · th-d8954b5343ba

Implanted direct-current field stimulator

Device · Implanted device; no ChEMBL entity. ClinicalTrials.gov search for implanted direct-current field stimulation returned no trial of this intervention (only an unrelated transcutaneous electrical nerve stimulation study).

Device Suggest a correction

Evidence & regulatory context

Mechanism: Implanted device; no ChEMBL entity. ClinicalTrials.gov search for implanted direct-current field stimulation returned no trial of this intervention (only an unrelated transcutaneous electrical nerve stimulation study).
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3258634 ↗1988Mixed findings

The effect of direct-current field on recovery from experimental spinal cord injury.

RatSpinal cord injuryCompressionInbred strain not specifiedn = 40 rats in total, four groups of 10Implanted device applying a direct-current field to the injured cord14 microA treatment stimulator versus 0 microA control stim…Implanted after acute spinal cord injury

Model: Clip compression injury of the spinal cord at C7-T1 at two severities (17 g and 53 g clip force)

In the milder 17 g injury there were no significant differences between treated and control rats. In the severe 53 g injury, direct-current stimulation improved inclined-plane scores, motor evoked potential amplitude and the number of labelled cells in the red nucleus, raphe nuclei and vestibular n…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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