Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating Toll-like receptor 4 signaling
MixedEndotoxin/LPSWistar rats; BALB/c mice as source of peritoneal macrophagesMalen = In vivo results reported as representative of eight indepen…Oral, dissolved in normal saline5 and 10 mg/kg in vivo; 10, 20, 40 and 80 micrograms/mL in…30 minutes after the start of resuscitation, after haemorrhagic shock and befor…
Model: Two-hit rat acute lung injury model, haemorrhagic shock to mean arterial pressure 45 +/- 5 mmHg for 1 hour then resuscitation with shed blood over 1 hour, followed by intratracheal lipopolysaccharide 0.2 mg/kg; in vitro peritoneal macrophages stimulated with lipopolysaccharide 1 micrograms/mL
Haemorrhagic shock plus intratracheal lipopolysaccharide raised serum carbon dioxide and caused severe pulmonary inflammation with neutrophil infiltration, oedema, haemorrhage and atelectasis, with strong alveolar TLR4 staining. Bupleurum polysaccharides at 5 and 10 mg/kg markedly reduced serum car…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.