THERAPY DOSSIER · th-d7655ddf96fe

NeuroAiD (MLC 601), a traditional Chinese herbal medicine

Nutraceutical · Multi-component herbal preparation; no ChEMBL entity queried as no defined chemical entity exists. Substantial human trial programme under MLC601/MLC901 (NeuroAiD, NeuroAiD II), including exact traumatic brain injury indications (NCT04487275, NCT04861688).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Multi-component herbal preparation; no ChEMBL entity queried as no defined chemical entity exists. Substantial human trial programme under MLC601/MLC901 (NeuroAiD, NeuroAiD II), including exact traumatic brain injury indications (NCT04487275, NCT04861688).
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04487275 ↗Injury indicationPHASE4unknown

MLC901 for Moderate to Severe Traumatic Brain Injury: Pilot Randomized Double-Masked Placebo-controlled Trial

Traumatic Brain Injury

Enrolment: 80 · Results not recorded

NCT04861688 ↗Injury indicationPHASE3completed

NeuroAiD II (MLC901) to Improve Cognitive Functioning in Non-surgical Mild Traumatic Brain Injury Patients

Traumatic Brain Injury

Enrolment: 182 · Results not recorded

NCT01336153 ↗PHASE4completed

Safety and Efficacy of MLC601 in 150 Iranian Patients After Stroke

Stroke

Enrolment: 150 · Results not recorded

NCT01696123 ↗PHASE2completed

Efficacy and Tolerability of MLC601 in Mild to Moderate Alzheimer Disease

Alzheimer Disease

Enrolment: 125 · Results not recorded

NCT00721825 ↗PHASE2completed

Phase II Pilot Study of NeuroAid In Enhancing Recovery After Stroke (TIERS)

Stroke · Cerebral Infarction

Enrolment: 40 · Results not recorded

NCT05621590 ↗EARLY_PHASE1completed

MLC901 in Hypoxic-ischemic Brain Injury Patients: Double-blind Randomized Placebo-controlled Trial

Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest

Enrolment: 35 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25331680 ↗2014Reported benefit

Therapeutic efficacy of Neuro AiD (MLC 601), a traditional Chinese medicine, in experimental traumatic brain injury.

RatTBIFluid percussionSprague-DawleyMale0.2 to 0.8 mg/kgEarly treatment 1 h post-injury and late treatment 4 days post-injury (the abst…

Model: Controlled fluid percussion injury model of traumatic brain injury

MLC 601 reduced cerebral contusion, neurological motor deficits, brain apoptosis and microglial activation after fluid percussion injury, with early treatment more effective than late treatment.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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