Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Male and femaleIntravenous (plasminogen); contralateral jugular vein infusion (argatroban)Human Glu-plasminogen 10 mg/kg; argatroban 10 mg/kg dissolv…Plasminogen administered before induction of thromboembolism; argatroban infusi…
Model: Acute cerebral thromboembolic ischaemic stroke with middle cerebral artery thrombus, in mice with experimentally varied blood plasminogen levels including plasminogen-deficient mice
Across the normal range, higher blood plasminogen levels were associated dose-relatedly with less ischaemic brain injury, greater dissolution of the middle cerebral artery thrombus, and reduced blood-brain barrier breakdown, matrix metalloproteinase-9 expression and microvascular thrombosis. Select…
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