THERAPY DOSSIER · th-d6a0ff5c97c4

Implanted wireless self-powered stimulator delivering pulse trains to midbrain median or dorsal raphe nuclei

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01362725 ↗PHASE2/PHASE3completed

Spinal Cord Stimulation For Heart Failure As A Restorative Treatment

Systolic Heart Failure

Enrolment: 20 · Results not recorded

NCT03082261 ↗NAcompleted

Sustainability of Pain Relief Utilizing a Multiple Waveform Enabled Neurostimulator (Prodigy/Proclaim IPG)

Chronic Pain · Intractable Pain

Enrolment: 269 · Results not recorded

NCT03546738 ↗NAcompleted

Spinal Cord Burst Stimulation for Chronic Radicular Pain Following Lumbar Spine Surgery

Back Pain With Radiation · Pain, Postoperative

Enrolment: 50 · Results not recorded

NCT05715138 ↗NAnot yet recruiting

Pallidal versus Subthalamic Deep Brain Stimulation for Cervical Dystonia (PASTS-CD)

Cervical Dystonia

Enrolment: 98 · Results not recorded

NCT03982888 ↗NAcompleted

Deep Brain Stimulation for Refractory Self-Injurious Behaviour in Children With Autism Spectrum Disorder

Autism Spectrum Disorder · Self-Injurious Behavior

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22963112 ↗2012Reported benefit

Midbrain raphe stimulation improves behavioral and anatomical recovery from fluid-percussion brain injury.

RatTBIFluid percussionImplanted intracerebral stimulating electrodeIntermittent 8 Hz pulse trains, with a higher frequency 24…Beginning 4 to 6 h after injury, with a delayed-start protocol beginning 7 days…

Model: Moderate parasagittal (right) fluid percussion traumatic brain injury

Early 8 Hz median and dorsal raphe stimulation restored reference memory acquisition and reduced cortical volume loss, early 8 Hz median raphe stimulation also restored spatial working memory, all protocols reversed forelimb reaching asymmetry, and 8 Hz median raphe stimulation reversed injury-indu…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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