THERAPY DOSSIER · th-d575f1687ffa

Human glial restricted progenitors and derived astrocytes pre-differentiated with ciliary neurotrophic factor or bone morphogenetic protein 4

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02478450 ↗PHASE1/PHASE2not yet recruiting

Phase 1/2a open-label safety study of transplantation of human glial restricted progenitor cells (hGRPs; Q-Cells) in ALS (ALTA-BOLT)

Amyotrophic Lateral Sclerosis

Enrolment: 30 · Results not recorded

NCT03887273 ↗PHASE1/PHASE2recruiting

Phase 1/2a open-label safety study of transplantation of human glial restricted progenitor cells (hGRPs; Q-Cells) in transverse myelitis

Transverse Myelitis

Enrolment: 9 · Results not recorded

NCT06163508 ↗Phase not recordedenrolling by invitation

Long term follow-up study for subjects who have received human glial restricted progenitor cells (hGRPs; Q-Cells)

Transverse Myelitis

Enrolment: 9 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23635322 ↗2013Reported benefit

Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord.

RatSpinal cord injuryHemisection / partialAthymic nude ratTransplantation into the lesion siteAcute transplantation at the time of lesion

Model: Cervical dorsal column lesion

Both human glial restricted progenitors and derived astrocytes survived and promoted regeneration of ascending sensory axons into the lesion, with no differences between differentiation protocols, and cells from frozen stocks behaved similarly.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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