THERAPY DOSSIER · th-d4fdca427764

Sesame oil

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL2108113 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Oleum sesami; Sesamum indicum oil; Sesamum indicum seed oil; Mayou
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07274371 ↗NAactive not recruiting

Brahmi-Gotu Kola oil padabhyanga versus sesame oil padabhyanga on sleep and mood in perimenopausal women

Sleep Disturbances in Perimenopause

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27732910 ↗2016Reported benefit

Sesame oil improves functional recovery by attenuating nerve oxidative stress in a mouse model of acute peripheral nerve injury: role of Nrf-2.

MouseCrushPeripheral-nerve crushC57BL/6 (inbred C57BL)Malen = 30 mice in total, 5 groups of 6Oral ingestion0.5, 1 or 2 mL/kg per dayDaily from the day of sciatic nerve crush

Model: Sciatic nerve crush

Sesame oil significantly reduced lipid peroxidation and increased nuclear Nrf2 and GAP43 expression in the injured sciatic nerve, and improved electrophysiological and functional recovery after crush injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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