THERAPY DOSSIER · th-d4b770874f1c

Napoleona vogelii methanolic leaf extract

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25149375 ↗2014Reported benefit

Wound healing effect of methanolic leaf extract of Napoleona vogelii (Family: Lecythidaceae) in rats.

RatWoundAlbino (specific strain not stated)Both sexesn = n=25 adult rats for the wound healing study (five groups of…Topical to the wound; oral for the acute toxicity (LD50) studyTopical extract at 5, 20 and 50 mg/mL w/v; acute toxicity (…After wound creation; exact interval not stated

Model: Incision skin wound (1.5 cm) created with a surgical blade under anaesthesia

Extract concentrations of 5, 20 and 50 mg/mL w/v produced significant (ANOVA, P<0.05) healing of the incision wounds, giving 125% to 140% healing versus control (100%), while Neobacin gave 150% healing at the third treatment regimen. Extract yield was 49.80% w/w dry matter and the LD50 was beyond t…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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