THERAPY DOSSIER · th-d4aece872d7c

End-to-end versus end-to-side neurorrhaphy (motor or sensory nerve graft)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02359825 ↗Injury indicationPHASE1completed

Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function

Peripheral Nerve Injury

Enrolment: 45 · Results not recorded

NCT05536609 ↗Injury indicationNArecruiting

Cast Or ePineural Suture for Digital Nerve Injuries - a Randomised Controlled Study

Digital Nerve Injury

Enrolment: 166 · Results not recorded

NCT04327154 ↗Injury indicationNAcompleted

Safety and Performance of TISSIUM Nerve Coaptation Device for Repair of Digital Nerve Discontinuities

Digital Nerve Injury

Enrolment: 12 · Results not recorded

NCT02718768 ↗Injury indicationPhase not recordedcompleted

Multi Center Prospective Observational Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma

Peripheral Nerve Injury(Ies)

Enrolment: 242 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21587041 ↗2011Mixed findings

End-to-end versus end-to-side motor and sensory neurorrhaphy in the repair of the acute muscle denervation.

RatOtherWistarMalen = 20

Model: Motor nerve lesion / muscle denervation (tibial nerve)

End-to-end neurorrhaphy best preserved muscle mass after motor nerve lesion in rats, while end-to-side repair with a sensory donor nerve performed worst.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Loading the evidence…