THERAPY DOSSIER · th-d4a254ed98d4

Low-magnitude, high-frequency whole-body vibration

Device · Device/physical therapy (whole-body vibration); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Device/physical therapy (whole-body vibration); not a ChEMBL entity
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02334410 ↗Injury indicationNAunknown

Early Intervention (Whole Body Vibration) to Reduce Bone Loss After Spinal Cord Injury

Spinal Cord Injury · Osteoporosis

Enrolment: 60 · Results not recorded

NCT01954940 ↗NAcompleted

Whole Body Vibration Therapy on Muscle Strength in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

Enrolment: 4 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26086026 ↗2015No effect reported

Low-Magnitude, High-Frequency Vibration Fails to Accelerate Ligament Healing but Stimulates Collagen Synthesis in the Achilles Tendon.

RatOtherSprague-DawleyFemalen = 32 rats in two groups of 16; biomechanics 14 joint pairs pe…Whole-body vibration on a platform coupled to an electromagnetic shaker, with weightbearing on both limbs0.3 g peak-to-peak acceleration at 30 Hz, platform displace…Started 2 days after operation

Model: Complete surgical transection of the left medial collateral ligament at the midsubstance, with immediate weightbearing allowed

Vibration did not change ultimate tensile load (injured p = 0.925) or structural stiffness (p = 0.542) of the transected ligament, nor histological appearance. In the intact Achilles tendon of the injured limb, vibration increased collagen 1 alpha 3-fold, interleukin 6 7-fold, cyclooxygenase-2 5-fo…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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