THERAPY DOSSIER · th-d49ba2441c10

Botulinum toxin type B (BTX-B)

Biologic · Cleaves SNARE complex; vesicle-associated membrane protein 2 (VAMP2/synaptobrevin) inhibitor

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Cleaves SNARE complex; vesicle-associated membrane protein 2 (VAMP2/synaptobrevin) inhibitor
Target: Vesicle-associated membrane protein 2 (VAMP2)
Injury models: Other
Reported indication: Not recorded
First approval: 2000
Development stage: Not recorded
ChEMBL record: CHEMBL1201569 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Botulinum toxin type b; BTX-B; Myobloc; Neurobloc; Rimabotulinumtoxinb
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02009540 ↗PHASE4unknown

Efficacy of Peri-trigonal Onabotulinumtoxin Injections in the Treatment of Refractory Idiopathic Detrusor Overactivity

Overactive Detrusor

Enrolment: 60 · Results not recorded

NCT02610868 ↗PHASE3completed

A Phase 3, Long-Term, Open-Label and Single-Arm Study of MYOBLOC in the Treatment of Troublesome Sialorrhea in Adult Subjects

Sialorrhea

Enrolment: 187 · Results not recorded

NCT01064518 ↗PHASE2completed

A Phase 2 Study to Evaluate the Efficacy and Safety of RT001, a Botulinum Toxin Type A Topical Gel, for Moderate to Severe Lateral Canthal Lines in Adults

Lateral Canthal Lines · Crow's Feet · Facial Wrinkles

Enrolment: 90 · Results not recorded

NCT02008136 ↗PHASE1unknown

New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain

Cervicalgia · Low Back Pain

Enrolment: 60 · Results not recorded

NCT04948177 ↗NAcompleted

Outcome of Gastric Fundus and Pylorus Botulinum Toxin A Injection in Obese Patients Class I-II With Normal Pyloric Orifice Structure

Obesity

Enrolment: 77 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21855233 ↗2011Reported benefit

Prevention of anastomotic thrombosis by botulinum toxin B after acute injury in a rat model.

RatOtherSprague-Dawleyn = 25Local injectionAfter anastomosis

Model: Acute femoral vessel transection and microvascular anastomosis

Botulinum toxin B reduced anastomotic thrombosis and increased vessel diameter after acute vessel repair up to 120 hours.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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