Tuning ligand density on intravenous hemostatic nanoparticles dramatically increases survival following blunt trauma.
RatHaemorrhage/shockUncontrolledSprague-Dawleyn = Pilot at 5 mg/kg n=3 and scaled up study n=13; in vitro dos…Intravenous, tail vein catheter5, 20 and 40 mg/kg in vivo in 0.5 ml PBS, with 5 mg/kg take…Immediately after injury
Model: Lethal liver trauma: medial liver lobe resected along a cautery marked arc of radius 1.3 cm from the suprahepatic vena cava under ketamine/xylazine 90:10 mg/kg, with animals allowed to bleed for 1 hour or until death
At 5 mg/kg the high ligand density nanoparticles raised 1 hour survival to 92.3 per cent versus 45 per cent for scrambled peptide (odds ratio 14.4, 95 per cent CI 1.36 to 143) and 47 per cent for saline, and reduced blood loss from 26.0 to 19.25 ml/kg. At 20 and 40 mg/kg the same particles were har…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.