THERAPY DOSSIER · th-d2750f491143

Rheinic acid (rhein), a major active component of rhubarb

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31037524 ↗2019Reported benefit

Rheinic acid ameliorates radiation-induced acute enteritis in rats through PPAR-gamma/NF-kappaB.

RatRadiationSprague-DawleyMaleOralAfter irradiation

Model: Acute radiation enteritis induced by a single 10 Gy abdominal X-ray dose delivered at 0.62 Gy/min

Rheinic acid promoted intestinal recovery, reduced bloody stool and histological damage, lowered pro-inflammatory cytokines, nitric oxide and malondialdehyde, raised superoxide dismutase and glutathione, and reduced apoptosis markers.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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