THERAPY DOSSIER · th-d208c6e51a4c

Poly(ethylene glycol)-functionalised hydrophilic carbon clusters (PEG-HCCs)

Drug · No confident ChEMBL match; PEG-functionalised hydrophilic carbon cluster nanoparticle antioxidant (research)

Evidence & regulatory context

Mechanism: No confident ChEMBL match; PEG-functionalised hydrophilic carbon cluster nanoparticle antioxidant (research)
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22866916 ↗2012Reported benefit

Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury.

RatTBIUnspecifiedIntravenous, 5 minute tail vein administration2 mg/kg, single doseAt the beginning of blood resuscitation, simulating hospital care after injury…

Model: Mild traumatic brain injury combined with haemorrhagic hypotension and staged resuscitation, including intravenous lactated Ringer's solution followed by oxygenation and blood reinfusion

A single 2 mg/kg intravenous dose of PEG-HCCs given at the start of resuscitation rapidly restored cerebral blood flow and normalised superoxide and nitric oxide levels compared with vehicle.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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