THERAPY DOSSIER · th-d1d2dcf4602d

Blood transfusion, dopamine infusion, and gamma-hydroxybutyrate

Procedure · Multi-component resuscitation procedure (blood transfusion + dopamine infusion + gamma-hydroxybutyrate); not a single molecule.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Multi-component resuscitation procedure (blood transfusion + dopamine infusion + gamma-hydroxybutyrate); not a single molecule.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 6799619 ↗1982Mixed findings

The effect of blood transfusion, dopamine, and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord.

RatSpinal cord injuryCompressionFemaleTransfusion intravenous; dopamine by infusionAfter injury

Model: Acute clip compression of the spinal cord at T-1 with a clip exerting 175 g pressure

Uninjured animals had mean arterial pressure 120.0 (SD 17.0) mmHg with grey and white matter flows of 74.2 (SD 22.3) and 18.7 (SD 6.7) ml/100 g/min, while injured untreated animals had 82.5 (SD 14.1) mmHg and flows of 13.3 (SD 12.1) and 3.9 (SD 3.9). Transfusion raised pressure to 127.5 (SD 13.7) m…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.

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