Effects of Acute Systemic Hypoxia and Hypercapnia on Brain Damage in a Rat Model of Hypoxia-Ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalen = 180 rats in nine groups of 20; sub-assays n = 5 for barrier…Inhalational via mechanical ventilation through a tracheostomy, tidal volume 9 mL/kg at 45 breaths per minute8% carbon dioxide targeted to PaCO2 60 to 80 mmHg; hypoxia…Begun 60 minutes after common carotid artery ligation
Model: Modified Levine preparation with permanent ligation of the left common carotid artery under pentobarbital anaesthesia, followed one hour later by 180 minutes of mechanical ventilation with hypoxic gas via tracheostomy
Hypercapnia was protective under mild to moderate hypoxia (PaO2 above 50 mmHg), improving cerebral blood flow and barrier integrity and reducing neuronal damage and apoptosis, but detrimental under severe hypoxia (PaO2 below 50 mmHg) where it lowered mean arterial pressure and cerebral blood flow a…
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