Tolerability and Pharmacokinetics of Ginkgolide B Injection Following Single- and Multiple-Ascending Doses in Healthy Participants
Healthy Volunteers
Enrolment: 36 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy Volunteers
Enrolment: 36 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Cervical spinal cord dorsal laceration injury
Platelet-activating factor receptor null mutant mice showed better grip and rotarod recovery, lower interleukin 6, vimentin, nestin and GFAP, and reduced proteoglycan deposition than wild-type injured mice. Ginkgolide B improved functional recovery in wild-type injured mice when given in the chroni…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Acute T10 spinal cord injury by the modified Allen weight-drop method
Ginkgolide B improved inclined plane and locomotor scores from day 3 to day 14, comparably with methylprednisolone, and inhibited JAK2 and STAT3 phosphorylation, raised the Bcl-2 to Bax ratio, lowered caspase-3 and reduced the apoptosis index.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.