Natural and engineered chemokine (C-X-C motif) receptor 4 agonists prevent acute respiratory distress syndrome after lung ischemia-reperfusion injury and hemorrhage.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMalen = n = 3-6 per treatment arm across three series (vehicle n =…Intravenous (femoral vein)Ubiquitin 0.7 or 0.14 micromol/kg; CXCL12 0.7, 0.14 or 0.07…Within 5 min of the start of fluid resuscitation, shortly after reperfusion at…
Model: Unilateral right lung ischaemia by hilar suture occlusion from t = 0 to 70 min plus haemorrhage to a mean arterial pressure of 30-40 mmHg from t = 40 to 70 min in anaesthetised ventilated rats, followed by reperfusion and saline fluid resuscitation to t = 300 min
Vehicle and CXCL12 (3-68) treated animals progressed to mild then moderate acute respiratory distress syndrome, whereas ubiquitin 0.7 micromol/kg, CXCL12 at 0.7 and 0.14 micromol/kg and the engineered monomeric and dimeric CXCL12 variants at 0.14 micromol/kg prevented it, stabilised blood pressure,…
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