THERAPY DOSSIER · th-cd3bde812872

Adipose-derived mesenchymal stem cells laden in porous gelatin microcryogels

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02298023 ↗PHASE2completed

Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells: Phase II Double-Blind Placebo-Controlled Randomized Clinical Trials

Rotator Cuff Tear

Enrolment: 24 · Results not recorded

NCT03259217 ↗PHASE1unknown

Prospects of Clinical Application of Mesenchymal Stem Cells Seeded in Chitosan Scaffold for Diabetic Foot Ulcers

Stem Cell Transplant

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33061373 ↗2020Reported benefit

Construction of Microunits by Adipose-Derived Mesenchymal Stem Cells Laden with Porous Microcryogels for Repairing an Acute Achilles Tendon Rupture in a Rat Model.

RatOtherSprague-DawleyMalen = 64 rats randomised into four groups (16 per group), assesse…Local injection into the tendon defect gap120 adipose-derived stem cell-laden gelatin microcryogels s…At the time of tendon transection surgery

Model: Acute Achilles tendon rupture created by transection of the right Achilles tendon, leaving a gap defect

Both the cell-laden microcryogel group and the cells-alone group stimulated Achilles tendon healing, with the cell-laden microcryogel group giving the best macroscopic appearance, histological morphology, Achilles functional index and biomechanical properties without adverse immune reaction. Gelati…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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