THERAPY DOSSIER · th-cd272a795d16

Cassia singueana methanolic root extract

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23790331 ↗2013Reported benefit

Antioxidant, hepatoprotective and hypolipidemic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication.

RatChemical/toxinWistarMaleIntraperitoneal5 mg/kgPretreatment before carbon tetrachloride intoxication in the acute study, and t…

Model: Acute and chronic carbon tetrachloride intoxication causing hepatic and oxidative injury

Extract treatment significantly reduced malondialdehyde in liver, kidney and heart (for example liver 0.18 to 0.15 nmol/mg), lowered serum aspartate aminotransferase, alanine aminotransferase, bilirubin and total cholesterol, and raised HDL cholesterol, superoxide dismutase and catalase relative to…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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