Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 33 rats contused, 24 randomised into 3 groups, final group…Local intraspinal injection at the graft and host interface, with the graft secured in aFGF, ChABC and fibrin glue2 to 4 intercostal nerve segments soaked for 30 minutes in…8 weeks after contusion injury (chronic phase)
Model: Chronic contusive spinal cord injury: T8 laminectomy and Infinite Horizon impactor with a 2.5 mm tip at 250 kdyne force, with repair surgery performed 8 weeks after injury
The combination produced robust catecholaminergic axon regeneration through the graft and back into the distal cord with astrocyte and Schwann cell integration, prevented the decline in locomotor score associated with the invasive repair and improved sphincter and bladder synchrony and voiding effi…
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