THERAPY DOSSIER · th-cb96ba5ede6f

Hydroalcoholic extract of Brazilian green propolis and its major isolated compound Artepillin C

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04480593 ↗PHASE2/PHASE3completed

Brazilian Green Propolis Extract (EPP-AF) in Patients Affected by COVID-19

Covid19

Enrolment: 120 · Results not recorded

NCT04800224 ↗PHASE2/PHASE3completed

Standardized Brazilian Green Propolis Extract (EPP-AF) as Adjunct Treatment for Hospitalized COVID-19

Covid19 · Inflammation

Enrolment: 200 · Results not recorded

NCT01142843 ↗PHASE2completed

Mouthwash Containing 5% Green Propolis for Control of Plaque and Gingivitis

Dental Plaque · Gingivitis

Enrolment: 25 · Results not recorded

NCT02052973 ↗PHASE1/PHASE2completed

Efficacy of Brazilian Green Propolis Varnish Against Streptococcus Mutans in Saliva

Streptococcal Infections · Saliva Altered

Enrolment: 11 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31745698 ↗2019Reported benefit

Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C.

MixedChemical/toxinWistar rats; mouse strain not statedMaleOralPropolis extract 30 to 300 mg/kg in the acute ethanol model…Acute model: oral pre-treatment 1 h prior to ulcer induction. Chronic model: th…

Model: Acute gastric ulcer induced in rats by ethanol and chronic gastric ulcer induced by acetic acid; Artepillin C healing tested in mice with installed ulcers

Oral pre-treatment with the propolis extract at 100 and 300 mg/kg prevented ethanol-induced gastric epithelial damage, reduced superoxide dismutase activity by about 11% and 26% respectively, increased glutathione S-transferase activity by around 20% and catalase by 80%, and at 300 mg/kg reduced re…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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